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Preliminary Study on the Healing Effect of Platelet-rich Fibrin for Soft Tissue Defects in Oral Implants

Author(s): C. Wang* and X. Ma
Hebei Provincial Eye Hospital, Xingtai, Hebei 054001, China

Correspondence Address:
Hebei Provincial Eye Hospital, Xingtai, Hebei 054001, China, E-mail:

Platelet-rich fibrin plays an active role in the repair of soft tissue defects in oral implants, but it still requires a long observation period, systematic description of platelet-rich fibrin to repair oral soft tissue defects in animal experiments to consolidate the relevant theoretical basis. New Zealand rabbits were selected as the test system. The experimental rabbits were randomly divided into 3 groups, platelet-rich fibrin group, collagen membrane group and blank control group. Each experimental rabbit was in the middle part of the hard palate, which was separated from the maxillary posterior incisors and left and right hard palate. A circular soft tissue full-thickness defect area was prepared by a tissue ring-cutting drill with a diameter of 5 mm at 2 mm of the mucosal edge. Three groups were implanted with platelet-rich fibrin membrane and collagen biofilm, and the blank control group was not treated. The healing morphology, wound healing rate, inflammatory response, collagen formation and angiogenesis were observed. The healing effect of soft tissue defects in platelet-rich fibrin oral implants was studied.

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