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Abstract

Preoperative Neutrophil Lymphocyte Ratio as a Prognostic Factor for Survival in Non-metastatic Renal Cell Carcinoma

Author(s): J. CHINDAPRASIRT, W. SIRITHANAPHOL1*
Medical Oncology Unit, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, 1Division of Urology, Department of Surgery, Faculty of Medicine, Khon Kaen University, Thailand

Correspondence Address:
Division of Urology, Department of Surgery, Faculty of Medicine, Khon Kaen University, Thailand, E-mail: [email protected]

The purpose of this study was to determine the prognostic role of preoperative neutrophil lymphocyte ratio in non-metastatic renal cell carcinoma. This retrospective study included 89 non-metastatic renal cell carcinoma patients who underwent nephrectomy between 2007 and 2017. The cut-off value of neutrophil lymphocyte ratio was determined on the basis of receiver operating characteristic analysis. Univariable and multivariable Cox regression models were performed. At a median follow-up of 6.7 y, 29 patients (34 %) had died. The cut-off value for neutrophil lymphocyte ratio was 2.5 by receiver operating characteristic analysis, with the area under the curve value of 0.77. High neutrophil lymphocyte ratio was associated with high T stage (p=0.024). Elevated neutrophil lymphocyte ratio (>2.5) was significantly associated with low overall survival. Multivariable analysis revealed that high preoperative neutrophil lymphocyte ratio was an independent risk factors for overall survival (hazard ratio 5.54, 95 % confidence interval- 1.06-28.95, p=0.043), along with age >65 (p=0.001) and large tumor size (p<0.001). Preoperative neutrophil lymphocyte ratio is an independent prognostic factor for low overall survival in patients with non-metastatic renal cell carcinoma undergoing nephrectomy.

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