Preparation And Evaluation Of Alginate-Chitosan Beads
Chitosan was reacted with sodium alginate in the presence of tripolyphosphate for bead formation. Diltiazem hydrochloride was used as the model drug. Spherical beads were produced with diameter in the range of 440-660 mm. The encapsulation efficiency was found to be 80-90%. There was a rapid initial drug release phase followed by a second release phase. But when glutaraldehyde or pectin is added the burst effect disappeared and they also decreased the percentage release of drug from the beads.