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Abstract

Preparation And Evaluation Of Dental Implants Containing Doxycycline Hydrochloride And Tinidazole In Biodegradable Carrier

Author(s): R Nagaraju, N Udupa

Dental implants of doxycycline hydrochloride and tinidazole were formulated using a biodegradable carrier, Poly (e-caprolactone), for the treatment of periodontitis. The in vitro drug release patterns and stability of these devices were studied. The formulations showed an initial burst release followed by more sustained release of the drugs throughout the period of study (42 days). The stability of the drugs were shown a marked improvement by formulating them in polymer matrix.

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