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Preparation and Evaluation of Rosuvastatin Calcium Nanosuspension and Solid Dispersion Tablets by Wet Granulation and Direct Compression Techniques using Tamarind Gum as a Binder

Author(s): S. Arjun, S. Karthik, K. Arjunan, S. Hariharan1, P. Seenivasan2 and V. Sankar*
Department of Pharmaceutics, 1Department of Pharmaceutical Chemistry, PSG College of Pharmacy, Coimbatore-641 004, 2Department of Pharmacy Practice, Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Chennai-600 116, India

Correspondence Address:
Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore-641 004, India, E-mail:

The current investigation was attempted to enhance the solubility and dissolution of rosuvastatin calcium through nanosuspension and solid dispersion techniques using tamarind gum as a binder. Rosuvastatin calcium nanosuspension and solid dispersion were prepared using high shear homogenisation and melt fusion techniques, respectively. Various pre-compression tests were performed for the powder blends. Finally, tablets containing these nanosuspensions and solid dispersions were evaluated for various post compression quality control parameters. The nanosuspension had a particle size of 453.3±23.6 nm with a neutral surface charge. Using the lyophilised nanosuspensions and solid dispersion, tablets were prepared by wet granulation and direct compression techniques. The results of in vitro drug release studies in pH 6.8 buffer showed enhanced solubility and release of rosuvastatin calcium from the tablets containing nanosuspension and solid dispersion in 60 min, when compared to the control tablets and a marketed tablet. Additionally, the property of tamarind gum to enhance the release of drug was also observed.

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