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Preparation And In Vitro Characterization Of Eudragit RL 100 Microspheres Containing 5-Flurouracil

Author(s): Jolly R Parikh, R. S. R Murthy, R. H Parikh

A relatively simple technique of preparing Eudragit RL-100 microspheres containing 5-Fluorouracil is described. The technique described is based on a condensation process and does not involve use of any harmful organic solvent, antiadhesion agents and surfactants. Discrete microspheres were obtained in the colloidal size range (3.79 ± 2.55 microns) and were evaluated with reference to entrapment efficiency and leaching rate profile.


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