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Preparation of a Menthol/beta-Cyclodextrin Inclusion Complex Using Supercritical CO2

Author(s): H. P. Lei, H. Zhang, F. H. Ge1*, Zh. W. Ye and Ch. H. Li2
School of Pharmaceutical Sciences, Xiangnan University, Chenzhou 423000, 1School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, 2School of Chemistry Biology and Environmental Engineering, Xiangnan University, Chenzhou 423000, China

Correspondence Address:
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China, E-mail:

A menthol/β-cyclodextrin inclusion complex was produced using supercritical CO2 while varying the temperature, pressure, co-solvent, inclusion time and depressurization time. The complex resulted was characterized with X-ray diffraction, scanning electron microscopy and differential scanning calorimetry. The characterization data confirmed the production of the inclusion complex at a maximum yield of 93.75 %. The dissolution rate of the complex was signiï¬?cantly higher than those of either untreated menthol or a physical mixture of menthol and β-cyclodextrin. This work thus demonstrated that supercritical CO2 could be successfully used to achieve inclusion complexes of menthol with β-CD.

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