Prodrugs Of Ibuprofen I : Preparation And Physico-Chemical Properties
The hydrochloride salts of N-Mannich bases of ibuprofenamide, which in turn was prepared using either morpholine or piperidine as the amine component. The characterization of the N-Mannich bases was done by element analysis, IR spectroscopy and NMR spectroscopy. Physico-chemical properties such as solubility, dissolution-rate and partition-coefficient were determined. The hydrochloride salt of N-Mannich bases of ibuprofenamide prepared using morpholine was found to be water soluble whereas the one prepared using piperidine was found to be water insoluble. The dissolution rate studies showed that dissolution rate of N-Mannich base of ibuprofenamide was pH-independent whereas that of piperidine was pH-dependent.