All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Prolonged Release Of Rifampicin From Internal Phase Of Multiple W/O/W Emulsion Systems

Author(s): Sushama Nakhare, S. P Vyas

Release rates of Rifampicin encapsulated in the internal aqueous phase of w/o/w emulsion stabilized by the gelling of the external phase (w/o/gel) were measured as the function of two formulation variables-The oil phases and internal phase volume. The release rate was significantly affected by the nature of the oil phase and decreased in the order of isopropyl myristate (IMP) > sesame oil > liquid paraffin, which was mainly due to maximum and minimum partition coefficient of drug in these phases respectively. The release rate of rifampicin from w/o/gel system was very prolonged. The release was enhanced with increasing in the volume of inner aqueous phase. These results show the utility of the w/o/gel type double emulsions for sustained release preparations and raise the possibility of control of drug release from the double emulsion system.


Google scholar citation report
Citations : 69022

Indian Journal of Pharmaceutical Sciences received 69022 citations as per google scholar report