Abstract

To investigate the effects of propofol anesthesia on learning and memory of offspring of late pregnant rats by inhibiting brain-derived neuro-affecting factor/tyrosine kinase B pathway. A total of 22 pregnant female rats were identified. Female rats fed for 3 w after pregnancy were randomly divided into a control group and a research group, with 11 rats in each group. The rats in the control group were fed normally, and the rats in the study group were given propofol 20 mg/kg with a concentration of 1 % by tail vein injection at a speed of 20 mg kg/h. The offspring of each group were randomly divided into the tyrosine kinase B excitation group and the non-tyrosine kinase B excitation group, with 25 offspring in each group. The expression of brain-derived neuro-affecting factor and tyrosine kinase B in hippocampus of rats in each group was observed by immunohistochemically staining. There was no significant difference in the blood gas index of each vein between the control group and the study group (p>0.05). Additionally, the count of passages across the initial platform location and the duration of stay in the third zone exhibited a substantial increase in comparison to the control group (p<0.05). Compared with the control group, the expression of brain-derived neuro-affecting factor and tyrosine kinase B in the hippocampus of the tyrosine kinase B-activated group decreased significantly (p<0.05), while the expression of brain-derived neuro-affecting factor and tyrosine kinase B in the hippocampus of the non-tyrosine kinase B-activated group decreased significantly (p<0.05). Maternal propofol anesthesia in late pregnancy can impair the learning and memory function of offspring rats, which may be achieved by inhibiting brain-derived neuro-affecting factor/tyrosine kinase B pathway.