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Protected Particulate Drug Carriers For Prolonged Systemic Circulation - A Review

Author(s): N Venkatesan, B Saravana Babu, S Sankar, S P Vyas

The field of protected particulates with longer circulation period in vivo is reviewed. Long circulating pharmaceutical carriers are the fastest growing field in the pharmaceutical research, today. Then uptake of particles by reticuloendothelial system poses problem in delivering the drug or active molecule to the appropriate site for a required period of time. This review discusses the possibility of using poly (ethylene glycol) and poly (ethylene oxide) as a coat to prolong the circulation half-life of the microparticulate system in vivo.