Abstract

Diabetic cardiomyopathy is the complication of diabetes and a serious health risk for diabetics. Pyrroloquinoline quinone, is a food-derived vitamin. The aim of this study was to investigate whether pyrroloquinoline quinone has a protective effect on the myocardium of patients with diabetic cardiomyopathy. We designed five groups of mice; control, diabetic cardiomyopathy, diabetic cardiomyopathy+pyrroloquinoline quinone-L, diabetic cardiomyopathy+pyrroloquinoline quinone-M, and diabetic cardiomyopathy+pyrroloquinoline quinone-H, and determined the changes of diabetic cardiomyopathy in each group based on the echocardiographic results of the mice. In addition, we also observed the myocardial tissue specimens of mice and found myocardial fibrosis was lower in pyrroloquinoline quinone group mice. To further explore the mechanism of pyrroloquinoline quinone affecting myocardial fibrosis, we used reverse transcriptase-polymerase chain reaction to measure the long noncoding RNA associated with myocardial fibrosis in mice, and found the expression of metastasis associated lung adenocarcinoma transcript 1, growth arrestspecific 5, and KCNQ1OT1 were higher in the groups of pyrroloquinoline quinone. This also indicated that pyrroloquinoline quinone improved myocardial fibrosis by affecting metastasis associated lung adenocarcinoma transcript 1, growth arrestspecific 5, and KCNQ1OT1 expressions.