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Quantitative analysis of clopidogrel bisulphate and aspirin by first derivative spectrophotometric method in tablets

Author(s): Madhuri D Game1, KB Gabhane1, DM Sakarkar2
1Vidyabharati College of Pharmacy, C. K. Naidu road, Camp, Amravati - 444 602, India 2Sudhakarrao Naik Institute of Pharmacy, Pusad - 445 204, Maharashtra, India

Correspondence Address:
Madhuri D Game Vidyabharati College of Pharmacy, C. K. Naidu road, Camp, Amravati - 444 602 India E-mail: [email protected]

A simple, accurate and precise spectrophotometric method has been developed for simultaneous estimation of clopidogrel bisulphate and aspirin by employing first order derivative zero crossing method. The first order derivative absorption at 232.5 nm (zero cross point of aspirin) was used for clopidogrel bisulphate and 211.3 nm (zero cross point of clopidogrel bisulphate) for aspirin.Both the drugs obeyed linearity in the concentration range of 5.0 μg/ml to 25.0 μg/ml (correlation coefficient r 2 <1). No interference was found between both determined constituents and those of matrix. The method was validated statistically and recovery studies were carried out to confirm the accuracy of the method.

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