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Abstract

Recent Advancement of Benzofuran in Treatment of Alzheimer’s Disease

Author(s): R. Sahu*, K. Shah, A. Misbah, Deepika Paliwal, Neha Sharma and Tara Rani
Department of Pharmaceutical Chemistry, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh 201310, 1Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh 281406, 2Department of Paramedical and Allied Sciences, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh 201310, India

Correspondence Address:
R. Sahu, Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh 281406, India, E-mail: rakeshsahu1100@gmail.com


Alzheimer's disease is a neurodegenerative disease that impairs motor and cognitive function it is spreading very quickly in the current scenario with a male:female ratio between 1:2 to 1:5 due to various causes associated with it which include education, diet and nutrition, sleep and cardiac rhythm and head trauma etc. Previously available drugs like tacrine failed to prove their efficacy and later were withdrawn from the market due to excess toxicity, lower solubility, and slow bioavailability. Among them, benzofuran-based drugs make a significant contribution because they are one of the important pharmacophores found both synthetically and naturally in heterocyclic compounds, with a wide range of therapeutic applications in the field of drug discovery that offers many opportunities for further improvement in anti-Alzheimer agents by acting on numerous prominent receptors. So, this article focuses on various benzofuran derivatives and their advancement in the treatment of Alzheimer’s disease with a summary of the synthesis of benzofuran and benzofuran-based derivatives which assist scientists in developing successful medications with the necessary pharmacological action.

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