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Relationship between Effect of Dietary Flavonoid Intake and Risk of Preeclampsia: A Research Study

Author(s): Bingrui Liu, Yanhua Liu, Ting Kang, Xianlan Zhao, Y. Cao and Quanjun Lyu*
Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan 450000, 1Department of Nutrition, 2Department of Obstetrics, The First Affiliated Hospital of Zhengzhou University, 3Department of Health, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China

Correspondence Address:
Quanjun Lyu, Department of Nutrition, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China, E-mail:

The purpose of this research was just to explore the connection between the risk of preeclampsia and the dietary consumption of flavonoids. This research adopted one matched case control study was devised with 1:1 matching by gestational age (±1 w), age (±3 y) as well as presence of gestational diabetes (yes/no). From March 2016 to June 2019, 440 pairs of participators in total were recruited. Information of dietary was attained with one questionnaire of 78 item semi quantitative food frequency. Dietary flavonoid intake was calculated using the residual method. Multivariate conditional logistic regression was adopted with the objective to assessing 95 % confidence intervals and the odds ratios. In comparison to the lowest intake quartiles, passive connections were surveyed between preeclampsia risk and the flavanones consumption (odds ratio=0.506, 95 % confidence interval=0.278-0.920, p=0.024), naringenin (odds ratio=0.477, 95 % confidence interval=0.266-0.853, p=0.02), luteolin (odds ratio=0.597, 95 % confidence interval=0.395-0.902, p<0.007) and quercetin (odds ratio=0.518, 95 % confidence interval=0.286–0.938, p<0.034) after adjustment for potential confounders. Consumption of total anthocyanidins, total flavan-3-ols and eight other specific flavonoids (hesperetin, apigenin, isorhamnetin, kaempferol, myricetin, daidzein, genistein and glycitein) was not associated with preeclampsia risk. The results suggest that increased dietary intake of flavanones (including naringenin), luteolin and quercetin is linked to a decreased preeclampsia risk.

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Citations : 66710

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