All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Relationship between Gastric Blood Perfusion and Gastric Mucosal Injury Induced by Acute Cerebrovascular Disease in Rats

Author(s): H. WANG AND D. YU2*
Department of Digestive Disease, Huangshi Central Hospital, Edong Healthcare Group, No.141 Tianjin Road, Huangshi City 435000, China

Correspondence Address:
D. YU, Department of Digestive Disease, Huangshi Central Hospital, Edong Healthcare Group, No.141 Tianjin Road, Huangshi City 435000, China, E-mail: [email protected]


This study aims to discuss the relationship between gastric perfusion and gastric mucosal injury induced by acute cerebrovascular disease in rats. Healthy adult male Wistar rats weighing 280-320 g are randomly divided into the following 4 groups: middle cerebral artery occlusion-reperfusion group, middle cerebral artery occlusion -sham group, gastric ischemia-reperfusion group and gastric ischemia-sham group, with 12 in each group. In gastric ischemia-reperfusion group, the similar changes occur to the mucous membrane of the rats, such as hyperaemia, edema, spotty or patchy hemorrhage and partial mucous exfoliation. There is no significant difference between middle cerebral artery occlusion-reperfusion group and gastric ischemia-reperfusion group in the number of gastrin cells and the expression of gas, but the number of gastrin cells and the expression of gas are significantly higher than those of their corresponding sham operation group, resulting in statistically significant difference. The gastric mucosal blood flow is significantly increased in the middle and high dose groups, which has significant difference compared with normal saline group (p<0.05). One of the important mechanisms of Calcitonin gene-related peptide protecting ischemic gastric mucosal injury is to increase gastric mucosal blood perfusion and improve microcirculation.

PDF