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Abstract

Reverse Micelles Of Timolol For Controlled Ocular Delivery

Author(s): A. K Rai, S. P Vyas, H. R Chitme

The reverse micelle is one of many models thought to have properties more nearly resembling the biological cellular environment, than does the traditional dilute-solution biochemical reaction system. The reverse micellar ocular system was prepared using cetyltriammonium bromide, span 60 alone and in combinations in organic solvent of isopropylpal mitate:isopropylmyristate (50:50). The designed systems were characterized for drug content and the process variables that effect the percent drug payload and release profiles of drug. The effect of hydration, temperature and ionic strength on drug pay load on reverse micellar systems had been considered for the present study. Systems were evaluated for in vitro performance. The drug release was recorded to follow approximate first order release kinetics. On the basis of in vitro characterization the selected systems were evaluated for in vivo activity. It was observed that the micellar systems exhibited prolonged and controlled biological response of timolol maleate.

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