Role Of Skin Cholesterol In Permeation Of Indomethacin
The possible role of skin cholesterol in modifying the percutaneous permeation of indomethacin was studied by employing lovastatin, an inhibitor of cholesterol synthesis. The decreased cholesterol content of solvent perturbed skin was maintained till 24 h by topical application of lovastatin (1.125 mg/cm2). Solvent perturbed-lovastatin treated viable skin excised after 24 h produced enhanced in vitro permeation of indomethacin. The time for 75% reduction in edema was significantly less in rats with perturbed-lovastatin treated skin as compared to that with normal skin.