All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Sensitive HPLC Method For Biovailability And Bioequivalence Studies Of Theophylline SR Formulations

Author(s): C. J Shishoo, S. S Savale

As part of ongoing programme on the development of a sustained release (SR) formulation of theophylline (200 mg capsule) and determination of its bioavailability, a specific, sensitive and simple HPLC method has been developed for the estimation of lower mg levels of theophylline in plasma. 8-Chlorotheophylline was used as an internal standard. With simple extraction of theophylline from plasma, the method has a, linearity range of 0.5 to 30 mg/ml and an average recovery of 79.32% for theophylline and 88.49% for the internal standard, respectively. Theophylline plasma concentration versus time data is presented for the test formulation (T) (SR capsule, 200 mg) and a standard formulation (S) (SR tablet, 200 mg). Different pharmacokinetic parameters for formulation T and formulation S were estimated and compared statistically for determination of their bioequivalence.

PDF

 
 
List of Supporting Conferences