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Simultaneous Determination Of Terbutaline Sulphate, Bromhexine Hydrochloride And Guaiphenesin In Three-Component Tablet Formulation By UV Spectrophotometry

Author(s): S Gangwal, P Trivedi

Derivative spectrophotometric and multiwavelength spectrophotometric methods have been developed for simultaneous determination of terbutaline sulphate, bromhexine hydrochloride and guaiphenesin in three-component tablet dosage forms. Methanolic hydrochloric acid (0.1 N) was used as the solvent. Terbutaline sulphate shows absorbance maximum at 279 nm, bromhexine hydrochloride shows two absorbance maxima, one at 318 nm and the other at 248 nm and guaiphenesin shows absorbance maximum at 274 nm. All the three drugs obey Beer's law in the concentration ranges employed for the methods. The methods have been validated statistically and by recovery studies.


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