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Simultaneous estimation of atorvastatin calcium and amlodipine besylate from tablets

Author(s): P Mishra, Alka Gupta, K Shah
Department of Pharmaceutical Sciences, Dr. H. S. Gour Vishwavidyalaya, Sagar - 470 003, India

Correspondence Address:
P Mishra GLA Institute of Pharmaceutical Research, 200/1, Yugal Niwas, Raman Reti, Vrindaban, Mathura India E-mail: [email protected]

The present communication deals with the development of a new, simple, specific, sensitive, rapid and economical procedure for simultaneous estimation of atorvastatin calcium and amlodipine besylate in a combined dosage form. The method is based on the native ultraviolet absorbance maxima of the two chemotherapeutic agents. As both compounds do not interact chemically in methanol, two wavelengths 246 nm for atorvastatin calcium and 360 nm for amlodipine besylate were used. Both the drugs obeyed Beer's law in the concentration range that was employed in the method.

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