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Simultaneous Estimation Of Chlorzoxazone And Paracetamol From Solid Dosage Forms Employing Simultaneous Equations And Derivative Spectrophotometry

Author(s): M. S Bhatia, S. G Kaskhedikar, S. C Chaturvedi

Two accurate and economical procedures for simultaneous estimation of chlorzoxazone and paracetamol in two component tablet formulation have been developed. The methods employ first derivative ultraviolet spectrophotometry and simultaneous equations for the simultaneous estimation of the two drugs. In 0.02 M sodium hydroxide, chlorzoxazone has two absorption maxima at 244 nm and 288 nm and paracetamol has an absorption maxima at 257nm. Both the drugs obey Beer's law in the concentration ranges employed for these methods. The results of analysis have been validated statistically and by recovery studies.


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