Simultaneous Estimation Of Valdecoxib And Tizanidine By Vierodt's And Q-Analysis UV Spectrophotometric Method
The simple, accurate and precise Vierodt's and Q-analysis UV Spectrophotometric method has been developed for the simultaneous determination of valdecoxib and tizanidine in combined tablet dosage form. Shimadzu UV-1601 instrument was used and the Î»max of valdecoxib and tizanidine was found to be 237 nm and 319 nm, respectively. In Q-analysis, the isoabsorptive point for both the drugs was found at 289.5 nm. The linearity range lies between 5-30 Î¼g/ml for valdecoxib and 0.5-3 Î¼g/ml for tizanidine at their respective wavelengths.