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Abstract

Simultaneous RP-HPLC estimation of trifluoperazine hydrochloride and chlordiazepoxide in tablet dosage forms

Author(s): Sejal K Patel, NJ Patel
S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva, Mehsana-382 711, India

Correspondence Address:
Sejal K Patel S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva, Mehsana-382 711 India [email protected]


A binary mixture of trifluoperazine HCl and chlordiazepoxide was determined using reversed-phase liquid chromatography method using methanol:water (97:03, v/v) pumped at a flow rate of 1.0 ml/min. Quantification was achieved with ultraviolet detection at 262 nm over concentration ranges of 0.1-1 and 0.5-5 μg/ml; mean accuracies were 101.05±0.47 and 98.97±0.33 %, respectively. The method was successively applied to tablet dosage forms as no chromatographic interferences from the tablet excipients were observed. The method retained its accuracy and precision when the standard addition technique was applied.

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