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Simultaneous Spectrophotometric Determination Of Losartan Potassium And Hydrochlorothiazide In Tablets

Author(s): M.B Shankar, F.A Mehta, K.K Bhatt, R.S Mehta, M Geetha

Two simple, accurate and precise methods for simultaneous estimation of losartan potassium and hydrochlorothiazide in combined dosage form have been described. First method employs formation and solving of simultaneous equations using 206.6 nm and 270.6 nm as two analytical wavelengths. Second method is dual wavelength method, which uses the difference of absorbance values at 206.6 and 261.4 nm for the estimation of losartan and absorbance values at 270.6 nm for the estimation of hydrochlorothiazide. Both the methods allow the simultaneous determination of losartan and hydrochlorothiazide in the concentration ranges employed for this purpose with the standard deviation of <1.0% in the assay of tablets.


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