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Abstract

Simultaneous Spectrophotometric Estimation Of Ciprofloxacin And Tinidazole From A Combined Dosage Form

Author(s): M. V Bombale, S. S Kadam, S. R Dhaneshwar

Two simple, precise and economical procedures for simultaneous estimation of ciprofloxacin and tinidazole in two component tablet have been developed. The methods employ program in the Multicomponent Mode of analysis of the instrument used and absorbency ratios for the simultaneous estimation of the two drugs. In 0.01N acetic acid, ciprofloxacin has an absorbance maxima at 276 nm, tinidazole has an absorbance maxima at 317 nm and isobestic point at 297 nm. Both the drugs obey the Beer's Law in the concentration ranges employed for these methods. the results of analysis have been validated statistically and by recovery studies. The methods show on interference by the compound from each other or by excipients when applied to formulation by means of UV-VIS spectroscopy and can be applied for routine simultaneous estimation of both drugs.

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