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Abstract

Simultaneous spectrophotometric estimation of famotidine and domperidone in combined tablet dosage form

Author(s): R Sahu, Preeti Nagar, S Bhattacharya, Deepti Jain
School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Bypass Road, Gandhinagar, Bhopal-462 036, India

Correspondence Address:
Deepti Jain School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Bypass Road, Gandhinagar, Bhopal-462 036 India E-mail: [email protected]


Two simple, accurate, precise and economical procedures for simultaneous estimation of famotidine and domperidone in two component tablet dosage form have been developed utilizing concept of standard addition. Both the methods utilize DMF/0.1N HCl (1:3) as solvent. Famotidine and domperidone at their respective lmax 267 nm and 285 nm shows linearity in the concentration range of 10-60 mg/ml. Wavelengths selected for estimation of famotidine and domperidone in simultaneous equation methods were 267 nm and 285 nm, respectively and for dual wavelength method were 275 nm, 291.1 nm and 275 nm, 257.9 nm, respectively. The result of analysis have been validated statistically, standard deviation lies in the range from 0.600-1.187, recovery studies range from 98.4-101.4% confirmed the accuracy of the proposed methods.

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