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Simultaneous Spectrophotometric Estimation Of Meclozine Hydrochloride And Nicotinic Acid From Combined Dosage Form

Author(s): S. B Bari, S. G Kaskhedikar

A simple and rapid simultaneous spectrophotometric method for the estimation of meclozine hydrochloride (MH) and nicotinic acid (NA) in two component tablet formulation has been reported using multicomponent mode and five mixed standards. MH and NA show absorbance maxima at 230 nm and 261 nm respectively. Beer's law is obeyed by MH in the range of 0.0 to 12.5 mcg/ml and by NA in the range of 0.0 to 50 rncg/ml. The method has been validated statistically as well as through a recovery study.


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