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Abstract

Simultaneous spectrophotometric estimation of paracetamol and metoclopramide hydrochloride in solid dosage form

Author(s): SJ Wadher, PR Pathankar, Manisha Puranik, RO Ganjiwale, PG Yeole
Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha- 442 001, India

Correspondence Address:
S J Wadher Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha- 442 001 India E-mail: [email protected]


Two simple, accurate, rapid and economical spectrophotometric methods have been developed for the simultaneous determination of paracetamol and metoclopramide hydrochloride from tablet dosage form. The first method developed employs formation and solving simultaneous equations using 248.6 nm and 275.6 nm as two wavelengths for formation of equations. Second method is absorbance ratio in which wavelengths selected were 265.6 nm as isoabsorptive point and 275.6 nm as lmax of paracetamol. Both the drugs and their mixtures obey Beer-Lamberts law at selected wavelengths at given concentration range. The methods have been validated statistically and by recovery studies. The results of analysis have been validated statistically and by recovery studies.

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