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Abstract

Solid Dispersions Of Curcumin

Author(s): Sarasija Suresh, Krishna Prasad

Solid dispersions of curcumin was studied to increase its aqueous solubility. Different carrier such as HPMC, HEC, PVP, high molecular weight PEG such as 1500, 4000, 20000, poloxamers such as Cremophor and Lutrol-127 were used in the preparation. Both fusion and solvent methods were adopted for the preparation of solid dispersions. Curcumin was successfully solubilised using Cremophor and PEG 20000 to get a concentration of 18 mg/ml. Increase in rate of dissolution compared to the pure drug was observed. Release pattern may be by first order kinetics.

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