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Solubility Studies Of Metronidazole In Binary Solvent Blends

Author(s): V. K Mourya, S. K Yadav, T. R Saini

The Extended Hildebrand Solubility Parameter Approach (EHSA) is suggested to predict the solubility of drug in binary and ternary solvent blends. The solubility profile of metronidazole Dioxane-water blends shows a bell shaped curve with solubility maxima different from the calculated ideal solubility. The approach was found better for the prediction of solubility.


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