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Abstract
Some cns depressant steroidal tetrazoles
Author(s): TR Bhardwaj, SN Singh, SK Kulkarni, D Paul, H Singh
Dept. of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014
Correspondence Address:
T R Bhardwaj Dept. of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014
Dept. of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014
Correspondence Address:
T R Bhardwaj Dept. of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014
Eight steroidal tetrazoles were studied for their CNS activity in mice. Their effects on analgesia, pentobarbital hypnosis, spontaneous motor activity and body temprature were examined. Compounds (2,3 and 4) showed CNS depressant activity in the above mentioned parameters. The other compounds tested had varying degrees of CNS activity. However, none of the compounds exhibited any anticonvulsant property in maximal electro-shock-induced convulsions, although compound (3) offered 80 percent protection against mortality.
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