Abstract

Author(s): S. A Patel, C. N Patel, I. S Rathod, B. N Suhagia, M. M Patel

A simple and sensitive spectrofluorimetric method was developed for the determination of atenolol in tablet dosage forms. The method was based on the reaction of atenolol with 0.1 N sodium hydroxide solution in boiling water bath, which shows strong fluorescence having excitation and emission wavelengths 278 nm and 302 nm, respectively. Linear relationship for the fluorescence - intensity was obtained in the concentration range of 5.0-25.0 μg/ml. The method was validated. statistically and was applied successfully for the determination of atenolol in tablet dosage forms.

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