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Spectrophotometric Determination Of Amiodarone And Ondansetron In Pharmaceutical Dosage Forms With Citric Acid - Acetic Anhydride Reagent

Author(s): T Siva Rao, C. S. P Sastry

A sensitive spectrophotometric method is presented for determining amiodarone and ondansetron. The drugs are extracted from formulations with chloroform from an alkaline medium and reacted with citric acid-acetic anhydride reagent to produce a bluish-violet colour having absorption maximum at 580 nm. Beer's law is obeyed between 2-12 μg/ml for amiodarone and ondansetron. The results agree within ± 1 .0% with official method.


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