All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Spectrophotometric Determination Of Captopril Through Charge-Transfer Complexation

Author(s): U Ajali, G. B Okide, N. J Nwodo

Captopril was quantitatively determined using chloranilic acid through charge-transfer complexation. Favourable conditions like time and temperature for the complex formation were determined. The wavelength for maximum absorption of light by the complex was 520 nm. The complex formation was maximum 30 min after mixing the reactants and room temperature was favourable for the complex formation. Captopril and chloranilic acid formed 1:1 complex in a mixture of dioxan:chloroform activated with dimethylsulphoxide. The association constant, molar absorptivity and free energy change for the complex were 0.6971 I/mol, 2.2462x102 l/ and 8.828 kcal/mol, respectively. Beer-Lambert's law was obeyed in the concentration range of 0.4- 1.4 mg% (w/v) of captopril. This method was employed in the analysis of captopril in dosage forms and the mean percentage recovery was 96.7%.


Google scholar citation report
Citations : 66710

Indian Journal of Pharmaceutical Sciences received 66710 citations as per google scholar report