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Spectrophotometric Determination Of Cefadroxil In Dosage Forms

Author(s): M. V. V Prasad, R Nagaraju, T. V Narayana

A simple and sensitive spectrophotometric method for the determination of cefadroxil anhydrous and its dosage forms is described. The method is based on the reaction of the drug with Folin-Ciocalteu reagent in presence of sodium hydroxide and stannous chloride to form a blue coloured chromogen having λmax at 970 nm. The absorbance was found to be linear with the concentration in the range of 5-25 μg/10 ml. The colour developed was stable up to 5 h.


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