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Abstract

Spectrophotometric Determination Of Lamivudine And Stavudine

Author(s): D. G Sankar, M. V. V. N Reddy, J. M Rajendra Kumar, T. K Murthy

A simple, sensitive spectrophotometric method has been developed for the determination of lamivudine and stavudine In pure and its pharmaceutical formulations. Lamivudine and stavudine give green coloured chromogens with 3-methyl-2-benzothiozolinone hydrazone hydrocloride and ferric chloride with absorption maximum at 660 nm and 630 nm, respectively. The chromogens obey Beer's law in the concentration ranges of 2.5 to 40 μg/ml and 2.5 to 12.5 μg/ml, respectively for lamivudine and stavudine.

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