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Spectrophotometric determination of promethazine hydrochloride.

Author(s): SL Bhongade, AV Kasture
Dept. of Pharmaceutical Sciences, Nagpur University, Nagpur-440 010,

Correspondence Address:
S L Bhongade Dept. of Pharmaceutical Sciences, Nagpur University, Nagpur-440 010

Two Spectrophotometric methods are described for the determination of Promethazine hydrochloride based on the formation of Choloroform extractable complexes exhibiting absorption maxima at 480 nm and 420 nm with sunset yellow and Bromocresol green, respectively. The colours are stable and obey the Beer's law in the concentration range of 2 to 10 mcg/ml. The methods are applicable for determination of promethazine hydrochloride in formulations.


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