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Abstract

Spectrophotometric Determination Of Promethazine Hydrochloride In Bulk Powder And In Its Dosage Forms

Author(s): M. B Devani, B. N Suhagia, S. A Shah

A simple spectrophotometric method for the determination of promethazine hydrochloride is described. The method is based on the oxidation of promethazine hydrochloride with acidic potassium permanganate to liberate formaldehyde which reacts in situ with acetylacetone in presence of ammonium acetate to give a colored product exhibiting maximum absorbance at 412 nm. The Lambert-Beer's law is obeyed in the concentration range of 10-80 mg of promethazine hydrochloride per ml of reaction mixture. The results obtained are comparable with those obtained by official methods.

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