Abstract

A colorimetric method has been developed for the determination of rofecoxib. Rofecoxib produces a yellow color chromogen in alkaline solution (pH 10-12), which exhibits a λmax at 355 nm. The system followed Beer-Lambert's Law in the concentration range of 5-40 μg/ml. The method is simple, economic, convenient, reproducible, precise and free from interference by excipients.