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Spectrophotometric Determination Of Rofecoxib In Pharmaceutical Dosage Forms

Author(s): Swati Rawat, S. K Jain

A colorimetric method has been developed for the determination of rofecoxib. Rofecoxib produces a yellow color chromogen in alkaline solution (pH 10-12), which exhibits a λmax at 355 nm. The system followed Beer-Lambert's Law in the concentration range of 5-40 μg/ml. The method is simple, economic, convenient, reproducible, precise and free from interference by excipients.


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