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Spectrophotometric determination of sulphadoxine in pharmaceutical dosage forms.

Author(s): S Raghuveer, I RK Raju, DK Vatsa, C MR Srivastava
Quality Control Laboratories, IDPL Hyderabad, Hyderabad-500 037,

Correspondence Address:
S Raghuveer Quality Control Laboratories, IDPL Hyderabad, Hyderabad-500 037

A senstive spectrophotometric method for the estimation of sulphadoxine was developed based on reaction with 4-dimethylaminocinnamaldehyde in orthophosphoric acid medium to form a stable and senstive choromogen. The red coloured chromogen obeys Beer's law over the concentration range of 0.4 to 4 mcg/ml. Pyrimrthamine in combined dosage forms which is present along with sulphadoxine did not interfere in the proposed method.


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