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Spectrophotometric Estimation of Aripiprazole in Tablets

Author(s): B. K. Jayanna*, T. D. Devaraj, G. Nagendrappa1 and N. Gowda
Department of Chemistry, B. N. M. Institute of Technology, Bangalore-560 070, 1Department of Post Graduate Studies And Research in Chemistry, Mysore University, Manasagangotri-570 008, India

Correspondence Address:
Department of Chemistry, B. N. M. Institute of Technology, Bangaluru-560 070, India

A simple, sensitive and rapid spectrophotometric method has been developed for the determination of aripiprazole in pharmaceutical formulations. The proposed method is based on the oxidation of drug with N-bromosuccinimide and unreacted N-bromosuccinimide bleaches the blue color of methylene blue and is measured at 663 nm. The increase in absorbance is directly proportional to the aripiprazole concentration and obeys Beer-Lambert’s law in the range of 5-20 μg/ml. The molar absorptivity and Sandell’s sensitivity, of the method were found to be 1.4906×104 l/mol/cm, 0.0300 µg/cm2, respectively. No interference was observed from excipients commonly found in tablets.

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