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Spectrophotometric estimation of ethamsylate and mefenamic acid from a binary mixture by dual wavelength and simultaneous equation methods

Author(s): Anju Goyal1, I Singhvi2
1Department of Pharmaceutical Chemistry, B. N. P. G. College of Pharmacy, Udaipur - 313 002, India 2Department of Pharmaceutical Sciences, M. L. Sukhadia University, Udaipur - 313 001, India

Correspondence Address:
Anju Goyal, Department of Pharmaceutical Chemistry, B. N. P. G. College of Pharmacy, India, E-mail: [email protected]

Two simple, accurate, economical and reproducible spectrophotometric methods for simultaneous estimation of two-component drug mixture of ethamsylate and mefenamic acid in combined tablet dosage form have been developed. The first developed method involves formation and solving of simultaneous equation using 287.6 nm and 313.2 nm as two wavelengths. Second developed method is based on two wavelength calculation. Two wavelengths selected for estimation of ethamsylate were 274.4 nm and 301.2 nm while that for mefenamic acid were 304.8 nm and 320.4 nm. Both the developed methods obey Beer's law in the concentration ranges employed for the respective methods. The results of analysis were validated statistically and by recovery studies.

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