Abstract

Author(s): K Chitra, K Sujatha, Iman Rabia Ahmed, K Shalini, B Lakshmi Priya, Sharon S Varghese

Two simple, accurate, rapid and sensitive methods have been developed for the estimation of ethamsylate in dosage forms. Method A is based on the nitrosation of the drug followed by chelation of the o-nitroso derivative formed with Cu++ ions forming a stable purple coloured chromogen, which shows absorption maximum at about 525 nm while method B is based on the reduction of Fe+++ to Fe++ ions by ethamsylate which then reacts with potassium ferricyanide to produce a blue coloured complex that shows maximum absorption at about 750 nm against reagent blank. In both the methods Beer's law was obeyed in the concentration range of 2-20 μg/ml.

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