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Abstract
Spectrophotometric estimation of famciclovir in bulk and tablet dosage form
Author(s): S Nizamuddin1, BM Gurupadayya1, MC Ravi1, YN Manohara1, S Appala Raju2
1 Department of Pharmaceutical Analysis, National College of Pharmacy, Shimoga - 577 201, India 2 Department of Pharmaceutical Analysis, H. K. E's College of Pharmacy, Gulbarga - 585 105, India
Correspondence Address:
B M Gurupadayya Department of Pharmaceutical Analysis, National College of Pharmacy, Shimoga - 577 201 India E-mail: bm_guru@yahoo.co.in
1 Department of Pharmaceutical Analysis, National College of Pharmacy, Shimoga - 577 201, India 2 Department of Pharmaceutical Analysis, H. K. E's College of Pharmacy, Gulbarga - 585 105, India
Correspondence Address:
B M Gurupadayya Department of Pharmaceutical Analysis, National College of Pharmacy, Shimoga - 577 201 India E-mail: bm_guru@yahoo.co.in
Two, simple, accurate, rapid and sensitive methods have been developed for the estimation of famciclovir in tablet dosage forms. Method A is based on the nucleophillic substitution product with Folin's reagent to form colored chromogen exhibiting absorption maximum at 454 nm with apparent molar absorptivity of 3.99×10 4 l/mol.cm and obeyed Beer's law in the concentration range of 2-10 µg/ml. Method B is based on diazotisation and coupling reaction with resorcinol to form colored chromogen exhibiting absorbance maximum at 386 nm with apparent molar absorptivity of 3.15×10 4 l/mol.cm and obeyed Beer's law in the concentration range of 7-21 µg/ml.
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