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Abstract

Spectrophotometric estimation of roxithromycin in tablet dosage forms

Author(s): BN Suhagia, SA Shah, IS Rathod, HM Patel, KR Doshi, VK Parmar
Department of Quality Assurance, L. M. College of Pharmacy, Navrangpura, Ahmedabad-380 009, India

Correspondence Address:
B N Suhagia Department of Quality Assurance, L. M. College of Pharmacy, Navrangpura, Ahmedabad-380 009 India E-mail: [email protected]


A simple and sensitive spectrophotometric method has been developed for determination of roxithromycin in its pharmaceutical dosage forms. In the proposed method, roxithromycin is oxidized with potassium permanganate to liberate formaldehyde, which is determined in situ using acetyl acetone in the presence of ammonium acetate to give a yellow-coloured chromogen with absorption maxima at 412 nm. The method is found to be linear in the concentration range of 10-75 µg/ml with regression coefficient of 0.9987. No significant difference was found between the proposed method and the reported method when two-tailed t-tests are applied. Various reaction parameters, such as concentration of potassium permanganate and reagent, time required for oxidation and maximum colour intensity, were optimized. The method was validated and can be used successfully to assay roxithromycin in its pharmaceutical dosage form, viz, tablets.

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