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Spectrophotometric estimation of tegaserod maleate in bulk drug and tablet formulation

Author(s): SJ Rajput1, HA Raj2
1 Pharmaceutical Quality Assurance Division, Pharmacy Department, Faculty of Technology and Engineering, M. S. University of Baroda, Vadodara - 390 001, India 2 Shri Sarvajanik Pharmacy College, Mehsana - 384 001, India

Correspondence Address:
H A Raj Shri Sarvajanik Pharmacy College, Mehsana - 384 001 India E-mail:

An extractive spectrophotometric method was developed for the estimation of tegaserod maleate. This method is based on the formation of a yellow colored ion-pair complex with bromo cresol green in phthalate buffer (pH 2.5). The complex was extracted into chloroform and absorbance measured at 415 nm. The calibration curve was found to be linear in the range of 1 to 30 μg/ml. The molar absorptivity and Sandell sensitivity values were found to be 2.9775 × 104l mol-1cm-1 and 0.2264 ×10-2 μg/cm2/0.001, respectively. The limit of detection and limit of quantification were found to be 0.0524 μg/ml and 0.1749 μg/ml, respectively. The method was successfully applied for assay in tablet formulation and the recovery was found to be in good agreement with label claim. The method was found to be precise, accurate and sensitive.

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