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Spectrophotometric Methods For The Determination Of Cefotaxime Sodium In Dosage Forms

Author(s): G Devala Rao, K Girish Kumar, K. P. R Chowdary

Two simple and sensitive spectrophotometric methods (A and B) In the visible region have beer1 developed for the determination of cefotaxime sodium (CFTS) in bulk and in dosage forms. Method A is based on the reaction of CFTS with nitrous acid under alkaline conditions to form a stable violet colored chromogen with absorption maximum of 560 nm and method B is based on the reaction of CFTS with 1,10-phenanthroline and ferric chloride to form a red colored Chromogen with the absorption maximum of 520mm.The color obeyed Beer's law in the concentration range of 100-500 μg/ml for method A and 1.6-16 μg/ml for method B, respectively. When pharmaceutical preparations containing CFTS were analysed, the results obtained by the proposed methods are in good agreement with the labeled amounts and are comparable with the results obtained using a UV spectrophotometric method.


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