All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Spectrophotometric Methods For The Determination Of Chlorzoxazona In Tablets

Author(s): C. S. P Sastry, R Chintalapati

Three simple and sensitive spectrophotometric methods (A-C) in visible region have been developed for the determination of chlorzoxazone. The reactions in all the three methods (A-C) are stoichiometric oxidations when the drug is treated with an excess of oxidant [nitrous acid (HNO2), method A; Nbromosuccinimide (NBS), method B; chloramines T (CAT), method C] in acidic medium. The unreacted oxidant is then estimated calorimetrically by using an oxidisable dye [cresyl fast violet acetate CFVA), method A; celestine blue (CB), method B; Gallocyanine (GC), method C]. Beer's law limits for methods A, B and C are 0.4 - 4.0 μg/ml, 0.4 5.0 μg/ml and 2-12 μg/ml respectively. No interference was observed from tableting additives and the applicability of the methods was examined by analyzing tablets containing chlorzoxazone.


Google scholar citation report
Citations : 66710

Indian Journal of Pharmaceutical Sciences received 66710 citations as per google scholar report