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Spectrophotometric Methods For The Determination Of Flutamide In Tablets

Author(s): P Nagaraja, H. S Yathirajan, H. R Arun Kumar, R. A Vasantha

Simple and sensitive spectrophotometric methods for the determination of flutamide in either pure form or in its pharmaceutical preparations are described. The first method is based on the reaction of reduced flutamide with Ehrlich reagent in alcohol medium to produce a yellow Schiff base with a λmax of 430 nm. In the second method, the diazotisation of reduced flutamide followed by complexation with molybdate ions and pyrocatechol in sulphuric acid medium to give a pink coloured complex with a λmax of 540 nm. Both the methods are highly reproducible and results of the assay of flutamide in tablets compare favourably with the reported method.


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